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Disruption of these well-regulated iron homeostatic mechanisms leads to increased iron accumulation within the cell, increased ROS generation, and a pro-oxidant intracellular environment that is pro-neurodegenerative and leads to ferroptosis of the neuronal cells

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E.1 Polycystic Ovary Syndrome (PCOS) PCOS affects 8-13% of reproductive-age women and is characterized by hyperandrogenism, oligo-anovulation, and polycystic ovarian morphology